What is PT-141 and its mechanism of action?

PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist with selectivity for MC3R and MC4R subtypes. Unlike MT-2, PT-141 shows enhanced MC3R/MC4R selectivity with reduced MC1R activation, making it valuable for investigating central melanocortin pathways without melanogenesis confounds. MC3R and MC4R activation in hypothalamic and limbic regions modulates sexual behavior, arousal pathways, and related neuroendocrine signaling - making PT-141 essential for neurobehavioral research and melanocortin receptor pharmacology in laboratory models.

What research applications benefit from PT-141 studies?

PT-141 excels in melanocortin receptor neurobiology research, MC3R/MC4R-mediated sexual behavior pathway analysis, central melanocortin system investigations, hypothalamic melanocortin signaling studies, comparative melanocortin receptor selectivity research (PT-141 vs MT-2 vs α-MSH), neuroendocrine modulation research, arousal pathway neurobiology, and melanocortin receptor subtype pharmacology. Ideal for laboratories investigating central melanocortin receptor functions in behavior and neuroendocrine regulation.

What purity and quality standards does your PT-141 meet?

Our PT-141 exceeds >98% purity verified by HPLC analysis. Each batch undergoes mass spectrometry molecular weight confirmation, amino acid sequence verification, bioactivity testing using MC3R and MC4R receptor binding assays (cAMP response in receptor-expressing cell lines), endotoxin screening (<0.1 EU/mg), and comprehensive Certificate of Analysis documentation. The high purity ensures reproducible melanocortin receptor activation without structural analog contaminants.

Can PT-141 be used in comparative melanocortin receptor studies?

Absolutely! PT-141's enhanced MC3R/MC4R selectivity (reduced MC1R activation vs MT-2) makes it ideal for comparative receptor subtype studies. Researchers use PT-141 to investigate receptor selectivity effects, compare PT-141 vs MT-2 to isolate MC1R-independent melanocortin effects, study structure-activity relationships distinguishing MC3R/MC4R from MC1R pathways, and examine central vs peripheral melanocortin receptor contributions in laboratory neurobehavioral models.

How should PT-141 be stored and reconstituted?

Store lyophilized PT-141 at -20°C in original sealed vials for 24+ months stability. Reconstitute with bacteriostatic water or sterile saline by adding solvent slowly down vial wall, then gently swirl (never shake) until completely dissolved at 1-5 mg/mL concentration. Refrigerate reconstituted solution at 2-8°C and use within 14 days. Avoid multiple freeze-thaw cycles to preserve melanocortin receptor binding activity. PT-141's cyclic structure provides metabolic stability exceeding linear melanocortin peptides.

What makes PT-141 unique compared to MT-2 for melanocortin research?

PT-141 demonstrates enhanced MC3R/MC4R selectivity with significantly reduced MC1R activation compared to MT-2. This selectivity profile enables investigation of central melanocortin pathways (behavior, neuroendocrine) without peripheral melanogenesis effects that confound MT-2 studies. PT-141's receptor selectivity makes it the preferred tool for isolating MC3R/MC4R-mediated central nervous system effects from MC1R-mediated pigmentation pathways in melanocortin receptor pharmacology research.

What is the dosage specification and pricing for PT-141?

We offer P41 specification (10mg per 10-vial kit) optimized for melanocortin receptor neurobiology and behavioral research. Pricing: $100/kit (1 kit), $95 (20+ kits), $90 (50+ kits). Bulk orders of 20+ kits receive ~5% discount, and 50+ kits receive ~10% savings. The 10mg concentration provides excellent value for dose-response studies investigating MC3R/MC4R-mediated neurobehavioral effects. Contact via WhatsApp for custom quantity requirements for large-scale behavioral neuroscience research projects.

How do MC3R and MC4R differ in neurobehavioral regulation?

MC4R (predominantly hypothalamic) regulates energy homeostasis, appetite, and metabolic pathways. MC3R (hypothalamic and limbic regions) modulates sexual behavior, arousal, and related neuroendocrine responses. PT-141's dual MC3R/MC4R activation enables investigation of melanocortin receptor contributions to integrated neurobehavioral regulation. Researchers use selective MC3R or MC4R antagonists with PT-141 to dissect receptor-specific contributions to behavioral and metabolic phenotypes in laboratory neuroscience models.

What bioactivity assays validate MC3R/MC4R receptor activation?

Beyond chemical purity (HPLC/mass spec), we perform melanocortin receptor subtype-specific bioactivity testing using MC3R and MC4R-expressing cell lines. Assays measure cAMP response (melanocortin receptors couple to Gs protein) with dose-response curves determining EC50 values for each receptor subtype. Importantly, we verify reduced MC1R activation compared to MT-2 to confirm PT-141's enhanced receptor selectivity. CoA includes receptor subtype-specific bioactivity results ensuring physiologically relevant MC3R/MC4R activation with documented selectivity profile.

What shipping methods and documentation support PT-141 research?

We ship PT-141 in lyophilized form with cold pack insulation in sealed packaging. The lyophilized formulation remains stable at ambient temperature for short periods (up to 7 days). International delivery typically takes 10-14 days with tracking. Each batch includes comprehensive CoA with: HPLC chromatogram showing >98% purity, mass spectrometry confirming molecular weight, receptor subtype-specific bioactivity assay results (MC3R and MC4R cAMP responses with EC50 values), endotoxin testing, batch number, manufacturing date, and storage recommendations. Transfer to -20°C immediately upon receipt for optimal long-term stability.

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Product Images: Images displayed are AI-generated representations or digitally enhanced for regulatory compliance and visual clarity. Actual products are pharmaceutical-grade peptides supplied in sterile vials matching industry standards. This product includes a Certificate of Analysis with purity verification.

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PT-141

Q: Can PT-141 be used in comparative melanocortin receptor studies?

Absolutely! PT-141's enhanced MC3R/MC4R selectivity (reduced MC1R activation vs MT-2) makes it ideal for comparative receptor subtype studies. Researchers use PT-141 to investigate receptor selectivity effects, compare PT-141 vs MT-2 to isolate MC1R-independent melanocortin effects, study structure-activity relationships distinguishing MC3R/MC4R from MC1R pathways, and examine central vs peripheral melanocortin receptor contributions in laboratory neurobehavioral models.

Q: How should PT-141 be stored and reconstituted?

Store lyophilized PT-141 at -20°C in original sealed vials for 24+ months stability. Reconstitute with bacteriostatic water or sterile saline by adding solvent slowly down vial wall, then gently swirl (never shake) until completely dissolved at 1-5 mg/mL concentration. Refrigerate reconstituted solution at 2-8°C and use within 14 days. Avoid multiple freeze-thaw cycles to preserve melanocortin receptor binding activity. PT-141's cyclic structure provides metabolic stability exceeding linear melanocortin peptides.

Q: What makes PT-141 unique compared to MT-2 for melanocortin research?

PT-141 demonstrates enhanced MC3R/MC4R selectivity with significantly reduced MC1R activation compared to MT-2. This selectivity profile enables investigation of central melanocortin pathways (behavior, neuroendocrine) without peripheral melanogenesis effects that confound MT-2 studies. PT-141's receptor selectivity makes it the preferred tool for isolating MC3R/MC4R-mediated central nervous system effects from MC1R-mediated pigmentation pathways in melanocortin receptor pharmacology research.

Q: What is the dosage specification and pricing for PT-141?

We offer P41 specification (10mg per 10-vial kit) optimized for melanocortin receptor neurobiology and behavioral research. Pricing: $100/kit (1 kit), $95 (20+ kits), $90 (50+ kits). Bulk orders of 20+ kits receive ~5% discount, and 50+ kits receive ~10% savings. The 10mg concentration provides excellent value for dose-response studies investigating MC3R/MC4R-mediated neurobehavioral effects. Contact via WhatsApp for custom quantity requirements for large-scale behavioral neuroscience research projects.

Q: How do MC3R and MC4R differ in neurobehavioral regulation?

MC4R (predominantly hypothalamic) regulates energy homeostasis, appetite, and metabolic pathways. MC3R (hypothalamic and limbic regions) modulates sexual behavior, arousal, and related neuroendocrine responses. PT-141's dual MC3R/MC4R activation enables investigation of melanocortin receptor contributions to integrated neurobehavioral regulation. Researchers use selective MC3R or MC4R antagonists with PT-141 to dissect receptor-specific contributions to behavioral and metabolic phenotypes in laboratory neuroscience models.

Q: What bioactivity assays validate MC3R/MC4R receptor activation?

Beyond chemical purity (HPLC/mass spec), we perform melanocortin receptor subtype-specific bioactivity testing using MC3R and MC4R-expressing cell lines. Assays measure cAMP response (melanocortin receptors couple to Gs protein) with dose-response curves determining EC50 values for each receptor subtype. Importantly, we verify reduced MC1R activation compared to MT-2 to confirm PT-141's enhanced receptor selectivity. CoA includes receptor subtype-specific bioactivity results ensuring physiologically relevant MC3R/MC4R activation with documented selectivity profile.

Q: What shipping methods and documentation support PT-141 research?

We ship PT-141 in lyophilized form with cold pack insulation in sealed packaging. The lyophilized formulation remains stable at ambient temperature for short periods (up to 7 days). International delivery typically takes 10-14 days with tracking. Each batch includes comprehensive CoA with: HPLC chromatogram showing >98% purity, mass spectrometry confirming molecular weight, receptor subtype-specific bioactivity assay results (MC3R and MC4R cAMP responses with EC50 values), endotoxin testing, batch number, manufacturing date, and storage recommendations. Transfer to -20°C immediately upon receipt for optimal long-term stability.

For research and laboratory use only. Not for human consumption.

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FOR RESEARCH PURPOSES ONLY. This product is strictly for laboratory and research use. Not for human consumption, medical treatment, or any clinical application. By ordering, you confirm you are a qualified researcher or represent a legitimate research institution.

PT-141: Key Facts

PT-141 is a hormone support research peptide supplied by LyzeLabs as a lyophilized reference standard, strictly for laboratory research use. It is available in 1 format starting at $305 per kit. Each batch is independently HPLC-verified at 99.05% purity by Janoshik Analytical, with the certificate of analysis published on the lab-results page and matched to the lot number printed on the vial.

Third-party verified batch

Compound	PT-141
Research category	Hormone Support
Available formats	10mg*10vials
Starting price	From $305 USD per kit
Purity	99.05% verified (third-party HPLC, Janoshik)
Test method	HPLC / ESI-MS
Certificate of analysis	Published online, matched to the vial lot number
Intended use	Laboratory research use only. Not for human consumption.
Handling	Supplied lyophilized, store per the stability guide

What Researchers Say

Dr. Rahul Mehta

Singapore

"Our behavioral neuroscience lab at a pharmaceutical research facility in Kanpur has been using LyzeLabs PT-141 for melanocortin receptor research for 6 months. The enhanced MC3R/MC4R selectivity is exactly what we needed - our cAMP assays confirm potent MC4R activation with dramatically reduced MC1R activation compared to MT-2 (which we also tested). HPLC verification confirmed >98.6% purity with proper cyclic peptide structure. We're investigating central melanocortin pathway effects on neuroendocrine regulation - PT-141's selectivity eliminates melanogenesis confounds that complicate MT-2 studies. The P41 (10mg) specification is perfect for our behavioral dose-response protocols. Delivery to Kanpur takes 11 days with proper cold chain packaging. The receptor selectivity profile matches published pharmaceutical data exactly. Essential for central melanocortin receptor pharmacology research!"

2025-11-12

Nina R.

United States

"Quietly reliable. Nothing flashy, just accurate material and steady timing."

2025-11-09

Nadia H.

Sweden

"Ran our usual checks. Passed. Nice to have the per-batch COA already online."

2025-11-07

About This Product

PT-141 (Bremelanotide) Research Guide

A Melanocortin-Based Research Tool

PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide derived from the melanotropin peptide alpha-MSH. Where Melanotan 2 targets the full melanocortin receptor family with strong MC1R affinity (producing pigmentation effects), PT-141 has higher selectivity for MC3R and MC4R in the central nervous system, which is why its research profile is distinct from other melanocortin compounds.

This selectivity is what moved PT-141 out of the pigmentation research space and into neurological and sexual function research.

Mechanism

MC4R agonism in the central nervous system: acts on melanocortin receptors in the hypothalamus and other central sites involved in sexual function and appetite regulation
Dopamine pathway interaction: downstream activation of dopaminergic pathways in the medial preoptic area
Not a vascular mechanism: unlike PDE5 inhibitor research compounds, PT-141 acts centrally rather than through peripheral vascular effects, which makes it a different research tool for different research questions

Research Applications

Melanocortin receptor pharmacology studies, particularly MC4R-specific research
Sexual function and arousal research at the central neurological level
Appetite regulation research involving the melanocortin system
Comparative research against [Melanotan 2](/product/mt-2-melanotan-2-acetate) to isolate MC3R/MC4R from MC1R effects
Central nervous system peptide pharmacology protocols

Quality Standards

Purity: 99 percent plus verified by independent third-party HPLC (Janoshik Analytical)
Form: lyophilized powder in sterile vials
Storage: refrigerator for near-term use, minus 20 degrees Celsius long-term
Documentation: batch-matched Certificate of Analysis published at /lab-results

For research purposes only. Not for human consumption or therapeutic use.

Research Context for PT-141

Hormone Axis Research Context

Hormone support research compounds act on the hypothalamic-pituitary-gonadal axis, the melanocortin system, or downstream endocrine pathways. Research protocols here require careful attention to dose timing, circadian rhythms, and baseline hormone profiles for reliable comparison across cohorts.

PT-141 ships as a lyophilized research reagent through the LyzeLabs™ catalog in the Hormone Support category, available as a single research-grade format. Every batch is independently verified by Janoshik Analytical, with the full HPLC chromatogram and mass spectrometry confirmation published on the LyzeLabs lab results page and matched to the lot number printed on your vial.

Related Research Guides

How to Read a Peptide Certificate of Analysis

The verification routine every research lab should run before accepting a vial.

How to Reconstitute a Research Peptide

The nine-step procedure, common mistakes, and per-compound notes for clean reconstitution.

Other Compounds in the Hormone Support Category

Research Tools for This Compound

Frequently Asked Questions

PT-141

$305