What is MT-2 Melanotan 2 and its mechanism of action?

MT-2 (Melanotan 2) is a synthetic melanocortin receptor agonist with high affinity for MC4R (melanocortin-4 receptor) and moderate affinity for MC1R and MC3R. MC4R activation modulates energy homeostasis, appetite regulation, and metabolic pathways, while MC1R activation stimulates melanogenesis (melanin production) in melanocytes. This dual MC1R/MC4R activity makes MT-2 essential for research into melanocortin receptor pharmacology, pigmentation biology, and central melanocortin pathway investigations in laboratory settings.

What research applications benefit from MT-2 studies?

MT-2 excels in melanocortin receptor pharmacology research, MC4R-mediated appetite regulation studies, melanogenesis pathway analysis, pigmentation biology investigations, central melanocortin system research, comparative melanocortin receptor selectivity studies, MC1R/MC4R signaling pathway analysis, energy homeostasis research, and melanocyte biology. Ideal for laboratories investigating melanocortin receptor family functions and pigmentation mechanisms.

What purity and quality standards does your MT-2 meet?

Our MT-2 Melanotan 2 Acetate exceeds >98% purity verified by HPLC analysis. Each batch undergoes mass spectrometry molecular weight confirmation, amino acid sequence verification, bioactivity testing using melanocortin receptor binding assays and melanogenesis stimulation assays in melanocyte cultures, endotoxin screening (<0.1 EU/mg), and comprehensive Certificate of Analysis documentation. The acetate salt form ensures optimal stability and solubility for research applications.

Can MT-2 be used in comparative melanocortin receptor studies?

Absolutely! MT-2 serves as a non-selective melanocortin agonist (activating MC1R, MC3R, MC4R) in comparative studies against selective agonists. Researchers use MT-2 to investigate receptor subtype-specific effects, compare MT-2 against α-MSH (endogenous melanocortin), study structure-activity relationships of melanocortin peptides, and examine MC4R vs MC1R contributions to metabolic vs pigmentation effects in controlled laboratory models.

How should MT-2 be stored and reconstituted?

Store lyophilized MT-2 at -20°C in original sealed vials for 24+ months stability. The acetate formulation enhances peptide stability. Reconstitute with bacteriostatic water or sterile saline by adding solvent slowly down vial wall, then gently swirl (never shake) until completely dissolved at 1-5 mg/mL concentration. Refrigerate reconstituted solution at 2-8°C and use within 14 days. Avoid multiple freeze-thaw cycles and protect from light to preserve melanocortin receptor binding activity.

What makes MT-2 unique for melanocortin receptor research?

Unlike selective melanocortin agonists, MT-2 activates multiple melanocortin receptor subtypes (MC1R, MC3R, MC4R) with high potency. This broad receptor activation enables investigation of melanocortin system-wide effects, comparison of receptor subtype contributions, and study of receptor cross-talk mechanisms. MT-2's cyclic structure (disulfide bridge) provides metabolic stability exceeding linear melanocortin peptides like α-MSH, making it ideal for extended receptor activation studies.

What is the dosage specification and pricing for MT-2?

We offer ML10 specification (10mg per 10-vial kit) optimized for melanocortin receptor research and melanogenesis studies. Pricing: $90/kit (1 kit), $85 (20+ kits), $80 (50+ kits). Bulk orders of 20+ kits receive ~6% discount, and 50+ kits receive ~11% savings. The 10mg concentration provides excellent value for extensive dose-response studies investigating MC4R-mediated metabolic effects and MC1R-mediated pigmentation. Contact via WhatsApp for custom quantity requirements.

How does MC4R activation differ from MC1R activation in research?

MC4R activation (central melanocortin pathway) modulates appetite, energy expenditure, and metabolic regulation via hypothalamic circuits. MC1R activation (peripheral melanocortin pathway) stimulates melanogenesis, increases eumelanin production, and regulates pigmentation in melanocytes and keratinocytes. MT-2's dual MC1R/MC4R activity enables researchers to investigate both pathways simultaneously or isolate receptor-specific effects using selective antagonists or receptor knockout models in comparative studies.

What bioactivity assays validate melanocortin receptor activation?

Beyond chemical purity (HPLC/mass spec), we perform dual bioactivity testing: (1) Melanocortin receptor binding assays using MC1R, MC3R, and MC4R-expressing cell lines measuring cAMP response (melanocortin receptors couple to Gs protein), and (2) Melanogenesis assays in melanocyte cultures measuring melanin production and tyrosinase activity. These functional assays confirm MT-2's ability to activate melanocortin receptors and stimulate downstream signaling. CoA includes bioactivity results ensuring physiologically relevant melanocortin activity.

What shipping methods and documentation support MT-2 research?

We ship MT-2 in lyophilized form with cold pack insulation and light-protected packaging. The lyophilized formulation remains stable at ambient temperature for short periods (up to 7 days). International delivery typically takes 10-14 days with tracking. Each batch includes comprehensive CoA with: HPLC chromatogram showing >98% purity, mass spectrometry confirming molecular weight, dual bioactivity assay results (receptor binding + melanogenesis), endotoxin testing, batch number, manufacturing date, and storage recommendations. Transfer to -20°C immediately upon receipt, store protected from light.

Home ProductsMT-2 (Melanotan 2)

Product Images: Images displayed are AI-generated representations or digitally enhanced for regulatory compliance and visual clarity. Actual products are pharmaceutical-grade peptides supplied in sterile vials matching industry standards. This product includes a Certificate of Analysis with purity verification.

MT210

MT-2 (Melanotan 2)

Q: Can MT-2 be used in comparative melanocortin receptor studies?

Absolutely! MT-2 serves as a non-selective melanocortin agonist (activating MC1R, MC3R, MC4R) in comparative studies against selective agonists. Researchers use MT-2 to investigate receptor subtype-specific effects, compare MT-2 against α-MSH (endogenous melanocortin), study structure-activity relationships of melanocortin peptides, and examine MC4R vs MC1R contributions to metabolic vs pigmentation effects in controlled laboratory models.

Q: How should MT-2 be stored and reconstituted?

Store lyophilized MT-2 at -20°C in original sealed vials for 24+ months stability. The acetate formulation enhances peptide stability. Reconstitute with bacteriostatic water or sterile saline by adding solvent slowly down vial wall, then gently swirl (never shake) until completely dissolved at 1-5 mg/mL concentration. Refrigerate reconstituted solution at 2-8°C and use within 14 days. Avoid multiple freeze-thaw cycles and protect from light to preserve melanocortin receptor binding activity.

Q: What makes MT-2 unique for melanocortin receptor research?

Unlike selective melanocortin agonists, MT-2 activates multiple melanocortin receptor subtypes (MC1R, MC3R, MC4R) with high potency. This broad receptor activation enables investigation of melanocortin system-wide effects, comparison of receptor subtype contributions, and study of receptor cross-talk mechanisms. MT-2's cyclic structure (disulfide bridge) provides metabolic stability exceeding linear melanocortin peptides like α-MSH, making it ideal for extended receptor activation studies.

Q: What is the dosage specification and pricing for MT-2?

We offer ML10 specification (10mg per 10-vial kit) optimized for melanocortin receptor research and melanogenesis studies. Pricing: $90/kit (1 kit), $85 (20+ kits), $80 (50+ kits). Bulk orders of 20+ kits receive ~6% discount, and 50+ kits receive ~11% savings. The 10mg concentration provides excellent value for extensive dose-response studies investigating MC4R-mediated metabolic effects and MC1R-mediated pigmentation. Contact via WhatsApp for custom quantity requirements.

Q: How does MC4R activation differ from MC1R activation in research?

MC4R activation (central melanocortin pathway) modulates appetite, energy expenditure, and metabolic regulation via hypothalamic circuits. MC1R activation (peripheral melanocortin pathway) stimulates melanogenesis, increases eumelanin production, and regulates pigmentation in melanocytes and keratinocytes. MT-2's dual MC1R/MC4R activity enables researchers to investigate both pathways simultaneously or isolate receptor-specific effects using selective antagonists or receptor knockout models in comparative studies.

Q: What bioactivity assays validate melanocortin receptor activation?

Beyond chemical purity (HPLC/mass spec), we perform dual bioactivity testing: (1) Melanocortin receptor binding assays using MC1R, MC3R, and MC4R-expressing cell lines measuring cAMP response (melanocortin receptors couple to Gs protein), and (2) Melanogenesis assays in melanocyte cultures measuring melanin production and tyrosinase activity. These functional assays confirm MT-2's ability to activate melanocortin receptors and stimulate downstream signaling. CoA includes bioactivity results ensuring physiologically relevant melanocortin activity.

Q: What shipping methods and documentation support MT-2 research?

We ship MT-2 in lyophilized form with cold pack insulation and light-protected packaging. The lyophilized formulation remains stable at ambient temperature for short periods (up to 7 days). International delivery typically takes 10-14 days with tracking. Each batch includes comprehensive CoA with: HPLC chromatogram showing >98% purity, mass spectrometry confirming molecular weight, dual bioactivity assay results (receptor binding + melanogenesis), endotoxin testing, batch number, manufacturing date, and storage recommendations. Transfer to -20°C immediately upon receipt, store protected from light.

For research and laboratory use only. Not for human consumption.

Premium pharmaceutical-grade MT-2 Melanotan 2 Acetate for advanced research applications

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FOR RESEARCH PURPOSES ONLY. This product is strictly for laboratory and research use. Not for human consumption, medical treatment, or any clinical application. By ordering, you confirm you are a qualified researcher or represent a legitimate research institution.

MT-2 (Melanotan 2): Key Facts

MT-2 (Melanotan 2) is a skin tanning research peptide supplied by LyzeLabs as a lyophilized reference standard, strictly for laboratory research use. It is available in 1 format starting at $290 per kit. Each batch is independently HPLC-verified at 99.37% purity by Janoshik Analytical, with the certificate of analysis published on the lab-results page and matched to the lot number printed on the vial.

Third-party verified batch

Compound	MT-2 (Melanotan 2)
Research category	Skin Tanning
Available formats	10mg*10vials
Starting price	From $290 USD per kit
Purity	99.37% verified (third-party HPLC, Janoshik)
Test method	HPLC / ESI-MS
Certificate of analysis	Published online, matched to the vial lot number
Intended use	Laboratory research use only. Not for human consumption.
Handling	Supplied lyophilized, store per the stability guide

What Researchers Say

Dr. Ananya Krishnan

Sweden

"Our pigmentation biology lab at an institutional research lab in Sydney has been using LyzeLabs MT-2 Melanotan 2 for melanocortin receptor research for 7 months. The dual MC1R/MC4R activity is excellent - our melanogenesis assays in melanocyte cultures show robust dose-dependent melanin production matching published MT-2 data. HPLC verification confirmed >98.5% purity with proper cyclic peptide structure (disulfide bridge intact). We're investigating MC4R-mediated metabolic effects vs MC1R-mediated pigmentation effects using selective antagonists - this requires high-purity MT-2 as the non-selective agonist reference. The ML10 (10mg) specification is perfect for our extensive dose-response protocols comparing MT-2 against α-MSH. Delivery to Sydney takes 12 days with light-protected cold chain packaging. The melanocortin receptor binding affinity matches pharmaceutical references. Essential for melanocortin pharmacology research!"

2025-11-13

Ken O.

United States

"Landed without issues. Paperwork online matched what we got."

2025-11-10

A. Novak

France

"Simple start to finish. Support answered everything before I paid."

2025-11-08

About This Product

Melanotan 2 (MT-2) Research Guide

A Synthetic Melanocortin Agonist

Melanotan 2, commonly abbreviated MT-2, is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH). It is a non-selective agonist of the melanocortin receptor family, binding MC1R through MC5R across the receptor spectrum. That broad receptor engagement is what distinguishes it from more selective melanocortin research tools like PT-141 (which is MC3R/MC4R selective) and gives MT-2 its characteristic research profile.

The Receptor Spectrum

MC1R: melanocyte activation and pigmentation pathway, the receptor that produces the well-known tanning effect in melanocortin research
MC2R: adrenal cortex response
MC3R and MC4R: central nervous system effects including appetite regulation and sexual function
MC5R: sebaceous gland and exocrine tissue effects

Because MT-2 binds all five receptors, it is the research tool for studies investigating pan-melanocortin effects rather than receptor-specific pharmacology.

Mechanism

Pigmentation pathway via MC1R: activates melanocytes and drives eumelanin synthesis
Central appetite and sexual function effects via MC3R/MC4R: overlaps with the PT-141 research space
Stability: the cyclic structure makes MT-2 more metabolically stable than native alpha-MSH

Research Applications

Melanocortin receptor pharmacology across the full MC1R-MC5R spectrum
Pigmentation biology and melanocyte research
Comparative research against [PT-141](/product/pt-141) to isolate MC3R/MC4R from MC1R effects
Appetite regulation research involving the melanocortin system
Sexual function research at the central neurological level

Quality Standards

Purity: 99 percent plus verified by independent third-party HPLC (Janoshik Analytical)
Form: lyophilized powder in sterile vials, supplied as the acetate salt
Storage: refrigerator for near-term use, minus 20 degrees Celsius long-term
Documentation: batch-matched Certificate of Analysis published at /lab-results

For research purposes only. Not for human consumption or therapeutic use.

Research Context for MT-2 (Melanotan 2)

Melanocortin Research Context

Melanocortin research compounds target the MC1R through MC5R receptor family, with effects spanning pigmentation, sexual function, appetite regulation, and inflammatory modulation. Research protocols focus on receptor selectivity, binding kinetics, and downstream signaling characterization.

MT-2 (Melanotan 2) ships as a lyophilized research reagent through the LyzeLabs™ catalog in the Skin Tanning category, available as a single research-grade format. Every batch is independently verified by Janoshik Analytical, with the full HPLC chromatogram and mass spectrometry confirmation published on the LyzeLabs lab results page and matched to the lot number printed on your vial.

Related Research Guides

How to Read a Peptide Certificate of Analysis

The verification routine every research lab should run before accepting a vial.

How to Reconstitute a Research Peptide

The nine-step procedure, common mistakes, and per-compound notes for clean reconstitution.

Other Compounds in the Skin Tanning Category

Melanotan 1

Research Tools for This Compound

Frequently Asked Questions

MT-2 (Melanotan 2)

$290