FOXO4-DRI
Cell-penetrating peptide for senescent cell and aging research
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If an independent HPLC assay of your lot comes back below the purity stated on our published Certificate of Analysis, we reship your order free. Verifiable, not a promise.
99.27% Purity Verified
HPLC / ESI-MS Tested
FOR RESEARCH PURPOSES ONLY. This product is strictly for laboratory and research use. Not for human consumption, medical treatment, or any clinical application. By ordering, you confirm you are a qualified researcher or represent a legitimate research institution.
FOXO4-DRI: Key Facts
FOXO4-DRI is a anti aging research peptide supplied by LyzeLabs as a lyophilized reference standard, strictly for laboratory research use. It is available in 1 format starting at $620 per kit. Each batch is independently HPLC-verified at 99.27% purity by Janoshik Analytical, with the certificate of analysis published on the lab-results page and matched to the lot number printed on the vial.
| Compound | FOXO4-DRI |
|---|---|
| Research category | Anti Aging |
| Available formats | 10mg*10vials |
| Starting price | From $620 USD per kit |
| Purity | 99.27% verified (third-party HPLC, Janoshik) |
| Test method | HPLC / ESI-MS |
| Certificate of analysis | Published online, matched to the vial lot number |
| Intended use | Laboratory research use only. Not for human consumption. |
| Handling | Supplied lyophilized, store per the stability guide |
Dr. Vivek Sharma
UAE
"Excellent senolytic peptide for our aging research. High purity and consistent effects."
2025-11-15
Prof. Barbara Nelson
United States
"Premium quality FOXO4-DRI for our senescence studies. Reliable batch-to-batch."
2025-11-12
Dr. Florian Koch
Germany
"High-quality peptide for our anti-aging research. Excellent documentation."
2025-11-08
About This Product
FOXO4 Peptide: Standard-Stereochemistry Senolytic for Comparative Research
Standard L-Form vs DRI Form
FOXO4 peptide (standard stereochemistry) targets the same FOXO4-p53 nuclear interaction as its D-retro-inverso counterpart, but uses conventional L-amino acids in forward sequence. The pharmacological target is identical. The practical difference is protease susceptibility: standard L-amino acid peptides are cleaved by endogenous proteases within minutes to hours in biological media, while the DRI form resists degradation. Researchers choose between them based on study design, not on which target they are investigating.
Mechanism
The peptide competes with endogenous FOXO4 for p53 binding, disrupting the nuclear complex that allows senescent cells to resist apoptosis. When p53 is freed from FOXO4 sequestration, the p53-dependent intrinsic apoptotic pathway activates in senescent cells. Selectivity arises from elevated FOXO4 expression and nuclear localization in senescent vs non-senescent cells.
When to Use Standard vs DRI Form
In vitro and short-duration cell culture studies frequently use the standard-stereochemistry form, where rapid protease degradation is less of a confound and the researcher can define precise exposure windows. The standard form is also appropriate for structural binding studies (crystallography, ITC, SPR) where D-amino acid modifications may complicate interpretation. FOXO4-DRI is preferred for extended studies where protease stability is a practical requirement.
Research Applications
- Cellular senescence research: FOXO4-p53 complex disruption and apoptosis induction
- In vitro senolysis: cell culture models of senescent cell clearance
- Structural pharmacology: peptide-protein binding characterization studies
- Comparative stereochemistry: L-form vs DRI-form activity and stability profiling
- Aging biology: downstream effects of selective senescent cell elimination
Quality Standards
- Purity: >99% by HPLC
- Identity: confirmed by ESI-MS
- Form: lyophilized powder, sterile vials
- Storage: -20°C, reconstitute with bacteriostatic water, use promptly
- Full COA at lyzelabs.com/lab-results
For research purposes only. Not for human consumption.
Research Context for FOXO4-DRI
Longevity and Anti-Aging Research Context
Anti-aging research peptides target pathways including telomere biology, mitochondrial function, cellular senescence, NAD metabolism, pineal signaling, and chromatin-level gene expression. Research protocols in this category often run over longer time horizons than other categories, which makes compound stability and storage discipline particularly important.
FOXO4-DRI ships as a lyophilized research reagent through the LyzeLabs™ catalog in the Anti Aging category, available as a single research-grade format. Every batch is independently verified by Janoshik Analytical, with the full HPLC chromatogram and mass spectrometry confirmation published on the LyzeLabs lab results page and matched to the lot number printed on your vial.
Related Research Guides
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How to Read a Peptide Certificate of Analysis
The verification routine every research lab should run before accepting a vial.
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Frequently Asked Questions
FOXO4-DRI
$620