What is Selank and its mechanism of action?

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) with anxiolytic and nootropic properties. Selank modulates GABAergic neurotransmission, enhances BDNF (brain-derived neurotrophic factor) expression, regulates monoamine metabolism (serotonin, dopamine), and influences immune system function. Its anxiolytic effects occur without sedation or cognitive impairment, while cognitive enhancement involves improved memory consolidation and learning. This dual anxiolytic-nootropic profile makes Selank essential for research into anxiety pathways, cognitive enhancement mechanisms, and GABA system modulation in laboratory neuroscience models.

What research applications benefit from Selank studies?

Selank excels in anxiolytic pathway research, GABAergic system modulation studies, BDNF-mediated neuroplasticity investigations, cognitive enhancement mechanism research, stress-induced anxiety pathway analysis, comparative anxiolytic studies (Selank vs benzodiazepines vs SSRIs), monoamine neurotransmitter regulation research, immune-neuro interactions, nootropic peptide pharmacology, and learning and memory consolidation studies. Ideal for laboratories investigating anxiety neurobiology, cognitive neuroscience, and peptide-based anxiolytics without sedative side effects.

What purity and quality standards does your Selank meet?

Our Selank exceeds >98% purity verified by HPLC analysis. Each batch undergoes mass spectrometry molecular weight confirmation, amino acid sequence verification (Thr-Lys-Pro-Arg-Pro-Gly-Pro), bioactivity testing using anxiety behavioral assays or GABA receptor modulation assays in neuronal cultures, BDNF expression analysis, endotoxin screening (<0.1 EU/mg), and comprehensive Certificate of Analysis documentation. The high purity ensures reproducible anxiolytic effects and cognitive enhancement without degradation products or contaminants.

Can Selank be used in comparative anxiolytic research?

Absolutely! Selank serves as a non-sedating anxiolytic reference peptide in comparative studies against benzodiazepines, SSRIs, or other peptide anxiolytics. Researchers use Selank to investigate GABAergic modulation without benzodiazepine-like sedation, compare peptide anxiolytics vs small-molecule drugs, study structure-activity relationships of anxiolytic peptides, and examine anxiolytic effects with concurrent cognitive enhancement (unlike sedatives that impair cognition) in laboratory anxiety and learning models.

How should Selank be stored and reconstituted?

Store lyophilized Selank at -20°C in original sealed vials for 24+ months stability. Reconstitute with bacteriostatic water or sterile saline by adding solvent slowly down vial wall, then gently swirl (never shake) until completely dissolved at 0.5-2 mg/mL concentration. Refrigerate reconstituted solution at 2-8°C and use within 14 days. Avoid multiple freeze-thaw cycles to preserve anxiolytic and nootropic bioactivity. Selank's synthetic stability provides excellent shelf life compared to natural peptides.

What makes Selank unique as an anxiolytic for research?

Unlike benzodiazepines that cause sedation, cognitive impairment, and dependence, Selank provides anxiolytic effects without these drawbacks. Selank enhances cognition while reducing anxiety - a unique dual benefit. Its GABAergic modulation differs mechanistically from direct GABA-A receptor agonism (benzodiazepines), involving indirect GABAergic enhancement and BDNF upregulation. This makes Selank invaluable for investigating non-sedating anxiolytic mechanisms, neuroprotective anxiolysis, and cognitive enhancement during stress in neuroscience research models.

What dosage variants and pricing are available for Selank?

We offer 2 specification options: SK5 (5mg per 10-vial kit) and SK10 (10mg per 10-vial kit). Pricing: SK5 at $70/kit (1 kit), $65 (20+ kits), $60 (50+ kits). SK10 at $110/kit (1 kit), $105 (20+ kits), $100 (50+ kits). Bulk orders of 20+ kits receive ~7-9% discount, and 50+ kits receive ~14-16% savings. The concentration range supports pilot anxiety studies through extensive dose-response cognitive enhancement research. Contact via WhatsApp for custom quantity requirements for large-scale behavioral neuroscience projects.

How does Selank modulate GABA and BDNF for dual anxiolytic-nootropic effects?

Selank enhances GABAergic neurotransmission indirectly (not direct receptor agonism like benzodiazepines), reducing anxiety without sedation. Simultaneously, Selank upregulates BDNF expression, promoting neuroplasticity, synaptic strengthening, and cognitive enhancement. This dual mechanism creates anxiolysis with concurrent cognitive improvement - impossible with GABAergic sedatives that impair cognition. Researchers use Selank to investigate GABA-BDNF pathway interactions, study non-sedating anxiolytic mechanisms, and examine neuroprotective stress adaptation in behavioral neuroscience models.

What bioactivity assays validate Selank's anxiolytic and cognitive effects?

Beyond chemical purity (HPLC/mass spec), we perform dual bioactivity testing: (1) Anxiety behavioral assays in research models (elevated plus maze, open field test) measuring anxiolytic efficacy without sedation, and (2) BDNF expression analysis in neuronal cultures using ELISA or Western blot, plus cognitive task performance (memory consolidation assays). These functional assays confirm Selank's dual anxiolytic-nootropic activity. CoA includes bioactivity results ensuring physiologically relevant anxiety reduction and cognitive enhancement without sedative confounds.

What shipping methods and documentation support Selank research?

We ship Selank in lyophilized form with cold pack insulation in sealed packaging. The lyophilized formulation remains stable at ambient temperature for short periods (up to 7 days). International delivery typically takes 10-14 days with tracking. Each batch includes comprehensive CoA with: HPLC chromatogram showing >98% purity, mass spectrometry confirming molecular weight, amino acid sequence verification, dual bioactivity assay results (anxiety behavioral data + BDNF expression levels), endotoxin testing, batch number, manufacturing date, and storage recommendations. Transfer to -20°C immediately upon receipt for optimal long-term stability.

Home ProductsSelank

Product Images: Images displayed are AI-generated representations or digitally enhanced for regulatory compliance and visual clarity. Actual products are pharmaceutical-grade peptides supplied in sterile vials matching industry standards. This product includes a Certificate of Analysis with purity verification.

SL5

Selank

Q: Can Selank be used in comparative anxiolytic research?

Absolutely! Selank serves as a non-sedating anxiolytic reference peptide in comparative studies against benzodiazepines, SSRIs, or other peptide anxiolytics. Researchers use Selank to investigate GABAergic modulation without benzodiazepine-like sedation, compare peptide anxiolytics vs small-molecule drugs, study structure-activity relationships of anxiolytic peptides, and examine anxiolytic effects with concurrent cognitive enhancement (unlike sedatives that impair cognition) in laboratory anxiety and learning models.

Q: How should Selank be stored and reconstituted?

Store lyophilized Selank at -20°C in original sealed vials for 24+ months stability. Reconstitute with bacteriostatic water or sterile saline by adding solvent slowly down vial wall, then gently swirl (never shake) until completely dissolved at 0.5-2 mg/mL concentration. Refrigerate reconstituted solution at 2-8°C and use within 14 days. Avoid multiple freeze-thaw cycles to preserve anxiolytic and nootropic bioactivity. Selank's synthetic stability provides excellent shelf life compared to natural peptides.

Q: What makes Selank unique as an anxiolytic for research?

Unlike benzodiazepines that cause sedation, cognitive impairment, and dependence, Selank provides anxiolytic effects without these drawbacks. Selank enhances cognition while reducing anxiety - a unique dual benefit. Its GABAergic modulation differs mechanistically from direct GABA-A receptor agonism (benzodiazepines), involving indirect GABAergic enhancement and BDNF upregulation. This makes Selank invaluable for investigating non-sedating anxiolytic mechanisms, neuroprotective anxiolysis, and cognitive enhancement during stress in neuroscience research models.

Q: What dosage variants and pricing are available for Selank?

We offer 2 specification options: SK5 (5mg per 10-vial kit) and SK10 (10mg per 10-vial kit). Pricing: SK5 at $70/kit (1 kit), $65 (20+ kits), $60 (50+ kits). SK10 at $110/kit (1 kit), $105 (20+ kits), $100 (50+ kits). Bulk orders of 20+ kits receive ~7-9% discount, and 50+ kits receive ~14-16% savings. The concentration range supports pilot anxiety studies through extensive dose-response cognitive enhancement research. Contact via WhatsApp for custom quantity requirements for large-scale behavioral neuroscience projects.

Q: How does Selank modulate GABA and BDNF for dual anxiolytic-nootropic effects?

Selank enhances GABAergic neurotransmission indirectly (not direct receptor agonism like benzodiazepines), reducing anxiety without sedation. Simultaneously, Selank upregulates BDNF expression, promoting neuroplasticity, synaptic strengthening, and cognitive enhancement. This dual mechanism creates anxiolysis with concurrent cognitive improvement - impossible with GABAergic sedatives that impair cognition. Researchers use Selank to investigate GABA-BDNF pathway interactions, study non-sedating anxiolytic mechanisms, and examine neuroprotective stress adaptation in behavioral neuroscience models.

Q: What bioactivity assays validate Selank's anxiolytic and cognitive effects?

Beyond chemical purity (HPLC/mass spec), we perform dual bioactivity testing: (1) Anxiety behavioral assays in research models (elevated plus maze, open field test) measuring anxiolytic efficacy without sedation, and (2) BDNF expression analysis in neuronal cultures using ELISA or Western blot, plus cognitive task performance (memory consolidation assays). These functional assays confirm Selank's dual anxiolytic-nootropic activity. CoA includes bioactivity results ensuring physiologically relevant anxiety reduction and cognitive enhancement without sedative confounds.

Q: What shipping methods and documentation support Selank research?

We ship Selank in lyophilized form with cold pack insulation in sealed packaging. The lyophilized formulation remains stable at ambient temperature for short periods (up to 7 days). International delivery typically takes 10-14 days with tracking. Each batch includes comprehensive CoA with: HPLC chromatogram showing >98% purity, mass spectrometry confirming molecular weight, amino acid sequence verification, dual bioactivity assay results (anxiety behavioral data + BDNF expression levels), endotoxin testing, batch number, manufacturing date, and storage recommendations. Transfer to -20°C immediately upon receipt for optimal long-term stability.

For research and laboratory use only. Not for human consumption.

Premium pharmaceutical-grade Selank for advanced research applications

Pick Your Size

Select Quantity

Researcher·1 Kit

Volume pricing

Per-kit price drops as you scale

Add 1 more kit

Unlock Lab pricing at $195/kit

+$190

extra savings

Total Price

$290

Free Worldwide Shipping

No minimum order. Customs handled.

Express Delivery

7-14 Days

Ships To

190+ Countries

Customs Handled

99% Success Rate

Stealth Packaging

Cold-Chain

Lab-Grade Guarantee

If an independent HPLC assay of your lot comes back below the purity stated on our published Certificate of Analysis, we reship your order free. Verifiable, not a promise.

99.28% Purity Verified

HPLC / ESI-MS Tested

View Report

FOR RESEARCH PURPOSES ONLY. This product is strictly for laboratory and research use. Not for human consumption, medical treatment, or any clinical application. By ordering, you confirm you are a qualified researcher or represent a legitimate research institution.

Selank: Key Facts

Selank is a sleep cognitive research peptide supplied by LyzeLabs as a lyophilized reference standard, strictly for laboratory research use. It is available in 2 formats starting at $290 per kit. Each batch is independently HPLC-verified at 99.28% purity by Janoshik Analytical, with the certificate of analysis published on the lab-results page and matched to the lot number printed on the vial.

Third-party verified batch

Compound	Selank
Research category	Sleep Cognitive
Available formats	5mg10vials, 10mg10vials
Starting price	From $290 USD per kit
Purity	99.28% verified (third-party HPLC, Janoshik)
Test method	HPLC / ESI-MS
Certificate of analysis	Published online, matched to the vial lot number
Intended use	Laboratory research use only. Not for human consumption.
Handling	Supplied lyophilized, store per the stability guide

What Researchers Say

Dr. Neha Gupta

Italy

"Our behavioral neuroscience lab at an institutional research lab in Amsterdam has been using LyzeLabs Selank for anxiolytic research for 7 months. The dual anxiolytic-nootropic bioactivity is remarkable - our anxiety behavioral assays (elevated plus maze) show significant anxiolytic effects without the sedation we observe with benzodiazepines. HPLC verification confirmed >98.7% purity with correct heptapeptide sequence (Thr-Lys-Pro-Arg-Pro-Gly-Pro) by mass spec. We're investigating Selank's GABAergic modulation mechanisms - the non-sedating anxiolysis is perfect for studying cognitive function during anxiety reduction (unlike sedatives that impair cognition). The SK5 and SK10 (5mg, 10mg) specifications are ideal for our dose-response protocols comparing Selank against benzodiazepines. Delivery to Amsterdam takes 12 days with cold chain packaging. Our BDNF expression assays confirm upregulation matching published data. Essential for peptide anxiolytic research!"

2025-11-14

Felix R.

United States

"Purity docs are right there on the site. Shipping beat my estimate."

2025-11-11

Sam D.

Italy

"Faster turnaround than the last two places I tried. Material held up."

2025-11-09

About This Product

Selank Research Guide

A Russian Anxiolytic Neuropeptide

Selank is a synthetic heptapeptide (TKPRPGP) developed at the Russian Academy of Medical Sciences as an analog of the endogenous immunomodulatory peptide tuftsin. It was designed specifically to retain tuftsin's behavioral and immunomodulatory effects while extending stability against enzymatic degradation, which native tuftsin lacks. The research lineage is primarily Russian, and Selank has been studied as a peptide anxiolytic without the sedation, dependency, or withdrawal profile of benzodiazepine-class compounds used in earlier anxiolytic research.

Mechanism

GABAergic modulation: modulates GABA neurotransmission without direct benzodiazepine receptor binding
Immunomodulatory effects: interacts with cytokine signaling, an echo of its tuftsin origin
Serotonergic pathway influence: documented effects on serotonergic signaling that contribute to the behavioral profile
Enkephalinase inhibition: one mechanistic hypothesis involves modulation of enkephalin degradation, affecting the endogenous opioid system

Research Applications

Anxiolytic neuropeptide research in animal behavioral models
Comparative research against GABA receptor agonists to isolate non-benzodiazepine anxiolytic mechanisms
Stress response and HPA axis research
Immunomodulatory and cytokine signaling studies
Cognitive research where stress and anxiety are the study variables
Combination research with [Semax](/product/semax), another Russian-origin neuropeptide with complementary mechanisms

Quality Standards

Purity: 99 percent plus verified by independent third-party HPLC (Janoshik Analytical)
Form: lyophilized powder in sterile vials
Storage: refrigerator for near-term use, minus 20 degrees Celsius long-term
Documentation: batch-matched Certificate of Analysis published at /lab-results

For research purposes only. Not for human consumption or therapeutic use.

Research Context for Selank

Sleep and Cognitive Research Context

Neuropeptides in this category are studied across circadian biology, memory consolidation, neuroprotection, and anxiolytic or nootropic pathways. Research models range from sleep architecture mapping in animal studies to behavioral learning paradigms and neurotransmitter-specific biomarker panels.

Selank ships as a lyophilized research reagent through the LyzeLabs™ catalog in the Sleep Cognitive category, with 2 variant options sized to different research protocols. Every batch is independently verified by Janoshik Analytical, with the full HPLC chromatogram and mass spectrometry confirmation published on the LyzeLabs lab results page and matched to the lot number printed on your vial.

Related Research Guides

How to Read a Peptide Certificate of Analysis

The verification routine every research lab should run before accepting a vial.

How to Reconstitute a Research Peptide

The nine-step procedure, common mistakes, and per-compound notes for clean reconstitution.

Other Compounds in the Sleep Cognitive Category

Research Tools for This Compound

Frequently Asked Questions

Selank

$290