IGF-DES
Truncated IGF-1 variant with enhanced potency for growth research
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If an independent HPLC assay of your lot comes back below the purity stated on our published Certificate of Analysis, we reship your order free. Verifiable, not a promise.
99.27% Purity Verified
HPLC Tested
FOR RESEARCH PURPOSES ONLY. This product is strictly for laboratory and research use. Not for human consumption, medical treatment, or any clinical application. By ordering, you confirm you are a qualified researcher or represent a legitimate research institution.
IGF-DES: Key Facts
IGF-DES is a growth hormone research peptide supplied by LyzeLabs as a lyophilized reference standard, strictly for laboratory research use. It is available in 1 format starting at $305 per kit. Each batch is independently HPLC-verified at 99.27% purity by Janoshik Analytical, with the certificate of analysis published on the lab-results page and matched to the lot number printed on the vial.
| Compound | IGF-DES |
|---|---|
| Research category | Growth Hormone |
| Available formats | 2mg*10vials |
| Starting price | From $305 USD per kit |
| Purity | 99.27% verified (third-party HPLC, Janoshik) |
| Test method | HPLC |
| Certificate of analysis | Published online, matched to the vial lot number |
| Intended use | Laboratory research use only. Not for human consumption. |
| Handling | Supplied lyophilized, store per the stability guide |
Dr. Nikhil Bhatia
Poland
"Excellent IGF variant for our growth research. High purity and enhanced activity."
2025-11-14
Prof. Timothy Clark
United States
"Premium quality IGF-DES for our anabolic studies. Consistent receptor activation."
2025-11-11
Dr. Mikhail Volkov
Russia
"High-quality growth factor for our research. Excellent documentation."
2025-11-07
About This Product
IGF-DES (IGF-1 DES 1,3) Research Guide
The Truncated IGF-1 Variant
IGF-DES, formally known as IGF-1 DES(1,3), is a truncated variant of insulin-like growth factor 1 in which the first three amino acids of the N-terminus are removed. This small structural change has significant pharmacological consequences: the deletion reduces binding affinity to IGF binding proteins (IGFBPs) in plasma, which otherwise rapidly scavenge native IGF-1 and limit its bioavailability at the receptor.
The result is a compound that reaches the IGF-1 receptor at meaningfully higher effective concentrations than native IGF-1 at matched doses, making it a sharper research tool for IGF-1 receptor pharmacology questions.
Mechanism
- IGF-1 receptor activation: same receptor as full-length IGF-1 and IGF-1 LR3, with downstream mTOR and PI3K/Akt pathway activation
- Reduced IGFBP binding: the DES(1,3) modification disrupts the binding site that IGFBPs use to scavenge native IGF-1
- Shorter half-life than IGF-1 LR3: the Long R3 modification in IGF-1 LR3 extends half-life more than the DES modification, which is why the two analogs occupy different research niches
- Localized activity profile: the shorter half-life makes IGF-DES closer to a pulse tool than a sustained-exposure tool
Research Applications
- IGF-1 receptor pharmacology research where IGFBP scavenging is the study variable
- Comparative research against [IGF-1 LR3](/product/igf-1lr3) to isolate short versus long half-life effects on the same receptor
- Muscle satellite cell research in protocols requiring pulsatile rather than sustained IGF signaling
- Protein synthesis and mTOR pathway research
Quality Standards
- Purity: 99 percent plus verified by independent third-party HPLC (Janoshik Analytical)
- Form: lyophilized powder in sterile vials
- Storage: refrigerator for near-term use, minus 20 degrees Celsius long-term
- Documentation: batch-matched Certificate of Analysis published at /lab-results
For research purposes only. Not for human consumption or therapeutic use.
Research Context for IGF-DES
Growth Hormone Research Context
Growth hormone research compounds are studied for their effects on protein synthesis, lipid metabolism, connective tissue remodeling, and the downstream IGF-1 axis. Research protocols here are sensitive to dose, timing, and the specific form of the compound, which is why accurate sourcing and a clear analytical profile matter more than in most other categories.
IGF-DES ships as a lyophilized research reagent through the LyzeLabs™ catalog in the Growth Hormone category, available as a single research-grade format. Every batch is independently verified by Janoshik Analytical, with the full HPLC chromatogram and mass spectrometry confirmation published on the LyzeLabs lab results page and matched to the lot number printed on your vial.
Related Research Guides
Other Compounds in the Growth Hormone Category
Frequently Asked Questions
IGF-DES
$305