AICAR
AMPK activator for metabolic and exercise mimetic research applications
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If an independent HPLC assay of your lot comes back below the purity stated on our published Certificate of Analysis, we reship your order free. Verifiable, not a promise.
99.47% Purity Verified
HPLC / ESI-MS / GC-FID Tested
FOR RESEARCH PURPOSES ONLY. This product is strictly for laboratory and research use. Not for human consumption, medical treatment, or any clinical application. By ordering, you confirm you are a qualified researcher or represent a legitimate research institution.
AICAR: Key Facts
AICAR is a fat loss research peptide supplied by LyzeLabs as a lyophilized reference standard, strictly for laboratory research use. It is available in 1 format starting at $310 per kit. Each batch is independently HPLC-verified at 99.47% purity by Janoshik Analytical, with the certificate of analysis published on the lab-results page and matched to the lot number printed on the vial.
| Compound | AICAR |
|---|---|
| Research category | Fat Loss |
| Available formats | 50mg*10vials |
| Starting price | From $310 USD per kit |
| Purity | 99.47% verified (third-party HPLC, Janoshik) |
| Test method | HPLC / ESI-MS / GC-FID |
| Certificate of analysis | Published online, matched to the vial lot number |
| Intended use | Laboratory research use only. Not for human consumption. |
| Handling | Supplied lyophilized, store per the stability guide |
Dr. Karthik Rao
Canada
"Excellent AMPK activator for our metabolic research. High purity and consistent effects."
2025-11-14
Prof. Steven White
United States
"Premium quality AICAR for our exercise physiology studies. Reliable results."
2025-11-11
Dr. Henrik Larsson
Sweden
"High-quality compound for our energy metabolism research. Excellent documentation."
2025-11-07
About This Product
AICAR Research Guide
An AMP Analog and AMPK Activator
AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) is a cell-permeable analog of AMP (adenosine monophosphate) that, once inside cells, is phosphorylated to ZMP, a molecule that mimics the natural AMP signal and activates AMP-activated protein kinase (AMPK). AMPK is the central cellular energy sensor, switching on catabolic pathways (fatty acid oxidation, glucose uptake) and switching off anabolic pathways (fatty acid synthesis, cholesterol synthesis) when cellular energy is low.
Because AMPK activation produces a transcriptional signature similar to exercise adaptation, AICAR has been studied as an exercise mimetic research tool for several decades.
Mechanism
- ZMP accumulation: AICAR is taken up by cells and phosphorylated to ZMP, an AMP mimetic
- AMPK activation: ZMP binds AMPK in the same allosteric site as AMP, activating the kinase without requiring actual cellular energy depletion
- Downstream metabolic shift: activated AMPK phosphorylates downstream targets that increase glucose uptake, fatty acid oxidation, and mitochondrial biogenesis
- Exercise mimetic transcriptional signature: research models show AICAR reproducing parts of the molecular response normally produced by endurance training
Research Applications
- AMPK pathway research in metabolic and exercise physiology contexts
- Exercise mimetic research investigating the molecular signature of endurance adaptation
- Mitochondrial biogenesis research through the AMPK/PGC-1 alpha axis
- Glucose uptake and insulin sensitivity research models
- Comparative research against other exercise mimetic compounds like [SLU PP-332](/product/slu-pp-332)
- Fatty acid oxidation research involving the malonyl-CoA/CPT1 pathway
Quality Standards
- Purity: 99 percent plus verified by independent third-party HPLC (Janoshik Analytical)
- Form: lyophilized powder in sterile vials
- Storage: refrigerator for near-term use, minus 20 degrees Celsius long-term
- Documentation: batch-matched Certificate of Analysis published at /lab-results
For research purposes only. Not for human consumption or therapeutic use.
Research Context for AICAR
Lipolysis and Fat Metabolism Research Context
Fat metabolism research peptides target lipolysis, mitochondrial fatty acid oxidation, brown adipose activation, or direct effects on adipocyte viability. Research protocols measure body composition, lipid panel markers, and tissue-specific fat mobilization under defined experimental conditions.
AICAR ships as a lyophilized research reagent through the LyzeLabs™ catalog in the Fat Loss category, available as a single research-grade format. Every batch is independently verified by Janoshik Analytical, with the full HPLC chromatogram and mass spectrometry confirmation published on the LyzeLabs lab results page and matched to the lot number printed on your vial.
Related Research Guides
Other Compounds in the Fat Loss Category
Frequently Asked Questions
AICAR
$310